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Test Your Knowledge

Hypercholesterolemia Resource Center Home Page
  1. Bempedoic acid reduces low-density lipoprotein cholesterol (LDL-C) levels by which mechanism of action?
  2. Statins can be considered for the management of hypercholesterolemia during pregnancy in which of the following scenarios?
  3. Adding bempedoic acid to background statin therapy significantly increases the risk of which of the following adverse events?
  4. The risk of muscle-related adverse events increases when bempedoic acid is taken in combination with which of the following daily doses of statins?
  5. In the CLEAR Outcomes trial, bempedoic acid demonstrated which of the following effects compared with statin therapy?

References

  1. Shriver K. Bempedoic Acid: A Novel LDL Cholesterol-Lowering Agent. Clin Diabetes 2020; 38(4):405-407.
  2. Poornima IG, Pulipati VP, Brinton EA, Wild RA. Update on Statin Use in Pregnancy. Am J Med 2023; 136(1):12-14.
  3. Lewek J, Bielecka-Dąbrowa A, Toth PP, Banach M. Dyslipidaemia management in pregnant patients: a 2024 update. Eur Heart J Open 2024; 4(3):oeae032.
  4. Costantine MM, West H, Wisner KL, et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development Obstetric-Fetal Pharmacology Research Centers (OPRC) Network, Bethesda, MD. A randomized pilot clinical trial of pravastatin versus placebo in pregnant patients at high risk of preeclampsia. Am J Obstet Gynecol 2021; 225(6):666.e1-666.e15.
  5. Ballantyne CM, Bays H, Catapano AL, et al. Role of Bempedoic Acid in Clinical Practice. Cardiovasc Drugs Ther 2021; 35(4):853-864. Erratum in: Cardiovasc Drugs Ther 2021; 35(4):865.
  6. Ballantyne CM, Banach M, Bays HE, et al. Long-Term Safety and Efficacy of Bempedoic Acid in Patients With Atherosclerotic Cardiovascular Disease and/or Heterozygous Familial Hypercholesterolemia (from the CLEAR Harmony Open-Label Extension Study). Am J Cardiol 2022; 174:1-11
  7. Ray KK, Bays HE, Catapano AL, et al; CLEAR Harmony Trial. Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol. N Engl J Med 2019; 380(11):1022-1032.
  8. Lincoff AM, Ray KK, Sasiela WJ, et al. Comparative Cardiovascular Benefits of Bempedoic Acid and Statin Drugs. J Am Coll Cardiol 2024; 84(2):152-162.
  9. Nicholls SJ, Nelson AJ, Lincoff AM, et al. Impact of Bempedoic Acid on Total Cardiovascular Events: A Prespecified Analysis of the CLEAR Outcomes Randomized Clinical Trial. JAMA Cardiol 2024; 9(3):245–253.

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