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Test Your Knowledge

Fertility Awareness Month Resource Center Home Page
  1. In the MEGASET-HR trial, a randomized, assessor-blinded noninferiority trial comparing HP-hMG (Menopur) and rFSH (Gonal-f) in predicted high responders (AMH ≥5 ng/mL) undergoing ICSI, which of the following outcomes was significantly improved with HP-hMG?
  2. In a study of controlled ovarian stimulation comparing hp-HMG (e.g., Menopur) and recombinant FSH (e.g., Gonal-f), serum progesterone on trigger day was significantly lower with hp-HMG than with recombinant FSH (0.45 vs 0.74 ng/mL; P = 0.001). Which mechanism best explains this difference?
  3. A laboratory study measured immunoassay interference from four categories of gonadotropin preparations comparable to those used clinically, including agents such as Gonal-f, Menopur, and menotropins. Which pattern of interference was observed across FSH and LH assays?
  4. In a propensity score matching analysis of infertile women with polycystic ovary syndrome (PCOS) undergoing IVF/ICSI with gonadotropin stimulation (including Gonal-f and Menopur/menotropins), GnRH antagonist pretreatment before stimulation was associated with which of the following outcomes?
  5. In a retrospective study of 727 infertile women aged 35–39 years undergoing IVF/ICSI with recombinant FSH (Gonal-f) in a luteal phase long protocol, which recombinant LH (rLH) supplementation strategy was associated with significantly improved live birth, implantation, and clinical pregnancy rates?

References

  1. Witz CA, Daftary GS, Doody KJ, Park JK, Seifu Y, Yankov VI, Heiser PW, on behalf of the MEGASET-HR Trial Group. Randomized, assessor-blinded trial comparing highly purified human menotropin and recombinant follicle-stimulating hormone in high responders undergoing intracytoplasmic sperm injection. Fertil Steril. 2020;114(2):321–330. doi:10.1016/j.fertnstert.2020.03.029
  2. Bosch E, Alamá P, Romero JL, Marí M, Labarta E, Pellicer A. Serum progesterone is lower in ovarian stimulation with highly purified HMG compared to recombinant FSH owing to a different regulation of follicular steroidogenesis: a randomized controlled trial. Hum Reprod. 2024;39(2):393-402. doi:10.1093/humrep/dead25
  3. Ersoy E, Gonel A. How FSH and LH analogs affect fertility hormone results?. Medicine (Baltimore). 2025;104(39):e44413. doi:10.1097/MD.0000000000044413
  4. Liang H, Zhao J, Chi Y, Cai J, Li G, Zhang Y, Liu L. Effect of GnRH antagonist pretreatment before controlled ovarian stimulation in antagonist protocol for infertile women with PCOS undergoing IVF/ICSI: a propensity score matching analysis. Medicine. 2025. doi:10.1097/MD.0000000000042965
  5. Shi YY, et al. Continuous versus flexible recombinant luteinizing hormone supplementation in women aged 35–39 years undergoing IVF with a luteal phase long protocol. Reprod Dev Med. doi:10.1097/RD9.0000000000000161
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