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Impact of germline BRCA status on clinical outcomes of patients with HR+/HER2- early breast cancer.

  • Journal of Clinical Oncology
  • May 2025
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Breast Cancer Awareness Month Peer-Reviewed Articles

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Abstract

Background: Germline pathogenic variants (PVs) in the BRCA1 and BRCA2 (gBRCA1/2) genesincrease the risk for breast cancer (BC) development.The prognostic significance of gBRCA1/2 in patients with hormone receptor-positive/HER2-negative (HR+/HER2) early BC is still controversial.

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